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To create a new blank document, choose the corresponding menu item:
Once you have created a document, you can change its layout (if you're creating a label) or size, by selecting File > Change Layout in the menu bar.
To open an existing document, select File > Open in the menu, or double-click on the document in Finder.
To save the current document using the same file name, choose File > Save in the menu, or File > Save As to save it under a new name.
To save a document as a template, choose File > Save as Template. See Using Templates for details about templates.
You can also use the Assistant to create or open documents, see the The Assistant section.